There are -a lot- of applications out there, which you can use on your desktop to tweet. Below is a summation of a few of them. If you have a suggestion then please feel free to contact me.

Windows

• DigiTweet
• MadTwitter
• Twitterlicious
• Twadget
• Digsby

Mac

• Twitterrific
• Tweetie
• Mac Lounge Beta
• Nambu
• Twitterpod

Linux

• Twitux
• gTwitter

Cross Platform

• DestroyTwitter
• Thwirl
• Tweetdeck
• Seesmic
• Spaz